Raj Padwal, MD

Office:   2F1.26 Walter C. Mackenzie Health Sciences Centre
Mail:   8440-112 Street Edmonton, Alberta T6G 2B7
Phone: 780-407-2732
Fax: 780-407-3132
Email:   rpadwal@ualberta.ca

Current Position


Associate Professor, Department of Medicine, University of Alberta

Director, Hypertension Clinic, University of Alberta


Research Areas


I have a background in general internal medicine, clinical pharmacology and clinical epidemiology. I am an academic internist and a health services researcher with an interest in cardiovascular risk management.  Specific areas of interest include primarily bariatric (obesity) care and hypertension addressing care-gaps. 


Research Goals


I am a physician, epidemiologist and health services researcher, with expertise in clinical pharmacology, general internal medicine and clinical epidemiology. I specialize in the care of adult patients with complex, multisystem disease, including (but not limited to) hypertension and other chronic cardiovascular diseases. I am the Director of the University of Alberta Hypertension Clinic and the Co-Chair of the Canadian Hypertension Education Program Recommendations Task Force. A large part of my research focuses on bariatric (obesity) care delivery in Canada.


Current Research Activities


a. Leading a 500-patient CIHR-funded prospective observational study (APPLES) examining the clinical, economic and humanistic (satisfaction, health-related quality of life) ramifications of protracted wait times for bariatric surgery.  This study involves a comparison of medically-treated, surgically-treated and wait-listed patients.


b. Leading a CIHR-funded study that aims to identify potential prioritization indicators for bariatric surgery (OASIS study).


c. Leading a CIHR-funded RCT examining the effectiveness of community-based education for obesity in reducing weight and preparing patients for bariatric intervention (EVOLUTION study).


d. Coinvestigator in an RCT examining the efficacy of pharmacist-led case management in improving blood pressure and lipid control in patients who have experienced a stroke or TIA.


e. a Site Lead for industry-sponsored clinical trials in obesity and hypertension.


Other Activities and Affiliations


Co-Chair, Canadian Hypertension Recommendations Task Force

CIHR Health Services Research Panels 1 and 2


Selected Publications


Padwal R, Klarenbach S, Wiebe N, Birch D, Karmali S, Manns B, Hazel M, Sharma AM, Tonelli M.  Bariatric surgery: a systematic review and network meta-analysis of randomized trials.  Obes Rev 2011;12:602-21.

Padwal RS, Gabr RQ, Sharma AM, Langkaas L, Birch DW, Karmali S, Brocks DR.  The effect of gastric bypass surgery on the absorption and bioavailability of metformin.  Diabetes Care. 2011;34:1295-300.

Oreopoulos A, Ezekowitz J, McAlister FA, Kalantar-Zadeh K, Fonarow GC, Norris CM, Johnson JA, Padwal RS*. Association between direct measures of body composition and prognostic factors in chronic heart failure.  Mayo Clin Proc 2010; 85:609-17. 

Padwal RS*, Majumdar SR.  New Drug Classes: Drug treatments for obesity: orlistat, sibutramine, and rimonabant.  Lancet 2007; 369:71-7.

Padwal R*, Sharma AM.  Treating severe obesity: morbid weights and morbid waits.  CMAJ 2009;181(11) 777-78.

Padwal RS*, Majumdar SR, Klarenbach S, Birch DW, Karmali S, McCargar L, Fassbender K, Sharma AM.  The Alberta population-based prospective evaluation of the quality of life outcomes and economic impact of bariatric surgery (APPLES) study: background, design, and rationale.  BMC Health Serv Res 2010; 0:284.

Oreopoulos A, Kalantar-Zadeh K, McAlister FA, Ezekowitz J, Fonarow GC, Johnson JA, Norris CM, Padwal RS*Comparison of direct body composition methods in patients with chronic heart failure.  J Card Fail 2010;16:867-72.

Padwal RS*, Sharma AM.  Prevention of cardiovascular disease: obesity, diabetes and the metabolic syndrome.  Can J Cardiol 2010; 26(Suppl C): 18C-20C.

Padwal RS*, Pajewsky NM, Allison DB, Sharma AM.  The Edmonton Obesity Staging System for predicting mortality in an overweight and obese population-representative cohort.  CMAJ 2011. 183;E1059-66.